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Product details

名称

Recombinant TDP43 Antibody

分子类型

抗体

别名

43kDa Tar DNA结合蛋白(TDP43)抗体

英文别名

物理外观

Liquid

货号

Ab130599-10μl

包装规格

10μl

级别

重组

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

4°C 短期储存（1-2 周）。-20°C下长期保存（24个月）。收货后建议分装。避免冷冻/解冻循环。

储存缓冲液

10mM PBS, 150mM NaCl, 50% Glycerol, 0.05% BSA, 0.02% Sodium azide, pH 7.4

防腐剂

0.02% Sodium azide

生化机理

DNA 和 RNA 结合蛋白，可调节转录和剪接。参与调控 CFTR 的剪接。它通过与该外显子 3'- 剪接位点附近多态区中的 UG 重复基团结合，促进 CFTR 第 9 号外显子的跳接。由此产生的异常剪接与囊性纤维化的典型病理特征有关。还可能参与微 RNA 的生物生成、细胞凋亡和细胞分裂。可通过与 HIV-1 长末端重复结合抑制 HIV-1 的转录。通过与 3' UTR 直接相互作用，稳定低分子量神经丝（NFL）mRNA。

免疫原

A synthetic peptide derived from human TDP43 (AA 1-61)

宿主种属

兔(Rabbit)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

特异性

TARDBP

阳性对照

WB: Mouse brain, Rat brain, HeLa, HEK293, K562, A431 and MCF7 lysates. IHC: Human glioma tissue. IF/ICC: HeLa cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

Format

Whole IgG

预测反应种属

鸡(Chicken)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！