Transferrin Receptor Mouse mAb

抗体

可溶性转铁蛋白受体抗体 | 可溶性转铁蛋白受体单克隆抗体 | 可溶性转铁蛋白受体标记抗体 | sTfR抗体 | sTfR单克隆抗体 | sTfR标记抗体 | Transferrin Receptor抗体 | Transferrin Receptor单克隆抗体 | Transferrin Receptor标记抗体 | TFRC抗体 | TFRC单克隆抗体 | TFRC标记抗体 | CD71抗体 | CD71单克隆抗体 | CD71标记抗体

CD 71 antibody | CD71 antibody | CD71 antigen antibody | IMD46 antibody | OTTHUMP00000208523 antibody | OTTHUMP00000208524 antibody | OTTHUMP00000208525 antibody | p90 antibody | sTfR antibody | T9 antibody | TFR 1 antibody | TfR antibody | TfR1 antibody

Liquid

Ab132253-10μg

10μg

≥95%(SEC-HPLC)

2-8°C储存

冰袋运输

长期储存2-8℃（24个月）；收货后建议分装。

137mM NaCl, 20mM Sodium citrate, 1mM EDTA, 2% Trehalose, 0.1% NP40, 0.095% Sodium azide, pH 6.0

0.095% Sodium azide

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. Post-translational: N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR). Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.

Native sTfR protein.

小鼠(Mouse)

人(Human)

TFRC

150 kDa

Unconjugated

Mouse IgG2a

单克隆抗体

kappa

Antigen affinity chromatography

[Ab132251] sTfR Mouse mAb as Capture antibody in CLIA, ELISA

Whole IgG