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名称

TRPM4 Mouse mAb

分子类型

抗体

别名

TRPM4抗体 | TRPM4单克隆抗体 | 转化受体电位阳离子通道亚家族M成员4抗体

英文别名

物理外观

Liquid

货号

Ab132713-10μl

包装规格

10μl

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

储存缓冲液

10mM PBS, 50% Glycerol, 1% BSA, 0.02% Sodium azide, pH 7.3.

防腐剂

0.02% Sodium azide

生化机理

Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca2+, it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822). Isoform 2. Lacks channel activity.

免疫原

Recombinant full length protein of human TRPM4 expressed in 293T.

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

TRPM4

阳性对照

WB: HEK293T transfected with pCMV6-ENTRY TRPM4 cDNA for 48 hrs; PC12 lysates. IHC: Human liver, liver carcinoma tissues.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

单克隆抗体

纯化方法

Protein G purified

克隆号

OTI14C3

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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