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名称

ZO1 tight junction Antibody

分子类型

抗体

别名

ZO1 tight junction抗体 | ZO1 tight junction多克隆抗体 | 紧密连接蛋白1抗体 | 紧密连接蛋白1多克隆抗体

英文别名

物理外观

Liquid

货号

Ab135462-10μl

包装规格

10μl

级别

无载体

浓度

见COA

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存4℃（1-2周）；长期储存-20℃（12个月）；收货后建议分装，避免反复冻融。

储存缓冲液

0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH 7.3

防腐剂

0.01% Sodium azide

生化机理

TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling. With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus. May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions.

免疫原

Recombinant full length protein of human ZO1 tight junction.

宿主种属

兔(Rabbit)

种属反应性

人(Human), 小鼠(Mouse) | 人(Human),小鼠(Mouse)

特异性

ZO1 tight junction

阳性对照

WB: C2C12 and HEK293 cell lysates. IF/ICC: MCF7 cells.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG

克隆类型

多克隆抗体

纯化方法

Immunogen affinity purified

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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