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Product details

名称

Bcl-XL Mouse mAb

分子类型

抗体

别名

英文别名

物理外观

Liquid

货号

Ab156202-50μl

包装规格

50μL

级别

无载体

浓度

≥95%(SDS-PAGE)

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

储存缓冲液

PBS, pH 7.4

生化机理

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis.

免疫原

Recombinant protein corresponding to human Bcl-XL

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

Human Bcl-XL

阳性对照

Flow Cytometry: Jurkat cells

SDS-PAGE

150.0 KDa

偶联

Unconjugated

亚型

Mouse IgG1 | IgG2b

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

IJ02/2C6 | AB04/4D7

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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