p53 Mouse mAb

抗体

肿瘤蛋白p53 | 肿瘤蛋白p53抗体 | 肿瘤蛋白p53小鼠单克隆抗体 | TP53抗体 | p53抗体 | 小鼠抗人肿瘤蛋白p53抗体

p53 induced gene 11 protein antibody | p53 induced protein antibody | PIG 11 antibody | PIG11 antibody | Tumor protein p53 inducible protein 11 antibody | Anti- p53 | Mouse Anti-human p53 | Monoclonal Anti- p53 antibody | p53 Mouse Monoclonal Antibody | p

Ab169235-10μl

10μl

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

PBS, pH 7.2

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2. However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2.

Recombinant protein corresponding to Human p53

小鼠(Mouse)

人(Human)

Human p53

WB: HEK293 and A431 whole cell lysates Flow Cytometry: HEK293 cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

EF03/6B12

Whole IgG

Pan paniscus,Pan troglodytes