Panitumumab (anti-EGFR), 表皮生长因子受体抗体

抗体

帕尼单抗 | EGFR抗体 | EGFR单克隆抗体 | EGFR药靶抗体 | ERBB1抗体 | ERBB1单克隆抗体 | ERBB1药靶抗体 | HER1抗体 | HER1单克隆抗体 | HER1药靶抗体

Panitumumab | ABX-EGF | Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody | Cell proliferation inducing protein 61 antibody | EGF R antibody | EGFR antibody | EGFR_HUMAN antibody | Epiderm

Liquid

Ab169317-5mg

5mg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

>95%

-80℃储存,避免反复冻融

超低温冰袋运输

长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

Flow,ELISA,Functional Assay,Kinetics (BLI),Kinetics (SPR)

CHO supernatant

人(Human)

人(Human)

EGFR

339177-26-3

26.8 kDa (Light Chain) & 52.0 kDa (Heavy Chain), under reducing conditions; 170.3 kDa, under non-reducing conditions.

Unconjugated

Human IgG2SA

重组抗体

kappa

Protein A purified

Primary antibody

抑制剂

表皮生长因子受体抗体

Whole IgG