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名称

Ozanezumab (anti-RTN4), 网状结构 4 的抗体

分子类型

抗体

英文别名

物理外观

Liquid

货号

Ab170567-100μg

包装规格

100μg

级别

无动物源

浓度

≥95%(SDS-PAGE&SEC-HPLC)

纯度

>95%

储存温度

-80℃储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。

储存缓冲液

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

防腐剂

生化机理

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

应用

ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)

来源

CHO supernatant

宿主种属

人(Human)

种属反应性

人(Human)

特异性

RTN4

CAS编号和信息

1310680-64-8

SDS-PAGE

150 kDa

亚型

Human IgG1

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

抗体类型

Primary antibody

作用类型

抑制剂

作用机制

网状结构 4 的抗体

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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