IGN523 (anti-CD98), 4F2hc 抗体

抗体

Ign523 | solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen | SLC3A2 | NACAE4F2 cell-surface antigen heavy chain | monoclonal 44D7 | MDU1antigen defined by monoclonal 4F2, heavy chain | Lympho

Ab175559-5mg

5mg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

-80℃储存,避免反复冻融

超低温冰袋运输

Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. Post-translational: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.

人(Human)

人(Human), 食蟹猴(Cynomolgus monkey) | 人(Human),食蟹猴(Cynomolgus monkey)

SLC3A2

145.66 kDa

Unconjugated

Human IgG1

重组抗体

kappa

Protein A purified

抗体

4F2hc 抗体

Whole IgG