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Product details

名称

Abrilumab (anti-Integrin α4β7), Integrin alpha-4/beta-7 抑制剂

分子类型

抗体

别名

阿利鲁单抗

英文别名

货号

Ab182732-100μg

包装规格

100μg

级别

无动物源

浓度

≥95%(SDS-PAGE&SEC-HPLC)

储存温度

-80℃储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。

防腐剂

生化机理

ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGB7: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

宿主种属

人(Human)

种属反应性

人(Human)

特异性

Integrin a4b7 (ITGA4&ITGB7)

CAS编号和信息

1342290-43-0

SDS-PAGE

143.8 kDa

偶联

Unconjugated

亚型

Human IgG2SA

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

作用类型

抑制剂

作用机制

Integrin alpha-4/beta-7 抑制剂

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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