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名称
Prasinezumab (anti-Alpha-synuclein), α-突触核蛋白结合剂的结合剂
分子类型
抗体
别名
普尼珠单抗 | Prasinezumab(抗α-突触核蛋白)
英文别名
Alpha synuclein antibody | Alpha-synuclein antibody | Alpha-synuclein, isoform NACP140 antibody | alphaSYN antibody | MGC105443 antibody | MGC110988 antibody | MGC127560 antibody | MGC64356 antibody | NACP antibody | Non A beta component of AD amyloid ant
物理外观
Liquid
货号
Ab182835-100μg
包装规格
100μg
级别
无动物源
浓度
≥95%(SDS-PAGE&SEC-HPLC)
储存温度
-80℃储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
生化机理
可能参与调节多巴胺的释放和运输。诱导微管相关蛋白 tau 纤维化。降低神经元对各种凋亡刺激的反应性,从而减少 caspase-3 的激活。 翻译后主要在丝氨酸残基上磷酸化。CK1 的磷酸化似乎发生在不同于其他激酶磷酸化的残基上。在突触核蛋白病变中,Ser-129 的磷酸化具有选择性和广泛性。在体外,Ser-129 处的磷酸化促进了不溶性纤维的形成。在渗透压作用下,Tyr-125 通过 PTK2B 依赖性途径发生磷酸化。神经退行性突触核蛋白病的标志性病变包含α-突触核蛋白,α-突触核蛋白通过酪氨酸残基的硝化修饰,可能还通过二酪氨酸交联生成稳定的寡聚体。泛素化。主要的共轭物是二泛素化形式。Met-1 处的乙酰化似乎对正常折叠和原生低聚物结构非常重要。
宿主种属
人(Human)
种属反应性
人(Human), 小鼠(Mouse), 食蟹猴(Cynomolgus monkey) | 人(Human),小鼠(Mouse),食蟹猴(Cynomolgus monkey)
特异性
SNCA
CAS编号和信息
1960462-19-4
SDS-PAGE
145.26 kDa
偶联
Unconjugated
亚型
Human IgG1-REM
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
作用类型
结合剂
作用机制
α-突触核蛋白结合剂的结合剂
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
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Research chemical ≥95%; HPLC

Research chemical ≥95%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%; HPLC.

item number:Ab182835-100μg
Product model:100μg
level: ≥95%; HPLC
Lead Time:30days
sold 893 Items
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100μg

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