Semorinemab (anti-Tau), 微管相关蛋白 tau 抑制剂

抗体

西瑞奈单抗 | 塞莫瑞奈单抗（抗陶氏剂）

AI413597 antibody | AW045860 antibody | DDPAC antibody | FLJ31424 antibody | FTDP 17 antibody | G protein beta1/gamma2 subunit interacting factor 1 antibody | MAPT antibody | MAPTL antibody | MGC134287 antibody | MGC138549 antibody | MGC156663 antibody |

Liquid

Ab182842-100μg

100μg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

-80℃储存,避免反复冻融

超低温冰袋运输

在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Post-translational: Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK: CDK1, CDK5, GSK-3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in PHF-tau), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK) in Alzheimer diseased brains. Phosphorylation decreases with age. Phosphorylation within tau's repeat domain or in flanking regions seems to reduce tau's interaction with, respectively, microtubules or plasma membrane components. Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity). PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur. Glycation of PHF-tau, but not normal brain tau. Glycation is a non-enzymatic post-translational modification that involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts (AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD.

人(Human)

人(Human), 食蟹猴(Cynomolgus monkey) | 人(Human),食蟹猴(Cynomolgus monkey)

MAPT

2159141-27-0

145 kDa

Unconjugated

Human IgG4SP-Opti

重组抗体

kappa

Protein A purified

抑制剂

微管相关蛋白 tau 抑制剂

Whole IgG