Izalontamab (anti-EGFR&HER3)

抗体

CD274药靶抗体 | EGFR&HER3抗体 | EGFR&HER3单克隆抗体 | EGFR&HER3药靶抗体 | EGFR抗体 | EGFR单克隆抗体 | EGFR药靶抗体 | HER3抗体 | HER3单克隆抗体 | HER3药靶抗体 | ERBB3抗体 | ERBB3单克隆抗体 | ERBB3药靶抗体

Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody | Cell growth inhibiting protein 40 antibody | Cell proliferation inducing protein 61 antibody | EGF R antibody | EGFR antibody | EGFR_HUMAN antibody | Epidermal growth factor recepto

Ab182999-100μg

100μg

无动物源

≥90%(SDS-PAGE&SEC-HPLC)

-80℃储存,避免反复冻融

超低温冰袋运输

在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

EGFR: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action. HER3: Binds and is activated by neuregulins and NTAK.

人(Human)

人(Human)

EGFR&ERBB3

2559704-24-2

197.22 kDa

Unconjugated

Human IgG1-REM | Human IgG1

重组抗体

kappa

Protein A purified

Whole IgG