UCHL1 Mouse mAb

抗体

泛素羧基端酯酶L1 | 抗泛素羧基端酯酶L1抗体 | 泛素羧基端酯酶L1小鼠单克隆抗体 | UCHL1抗体 | 小鼠抗人泛素羧基端酯酶L1抗体

Epididymis luminal protein 117 antibody | Epididymis secretory protein Li 53 antibody | HEL 117 antibody | HEL S 53 antibody | NDGOA antibody | Neuron cytoplasmic protein 9.5 antibody | OTTHUMP00000218137 antibody | OTTHUMP00000218139 antibody | OTTHUMP00

Ab183834-10μl

10μl

无载体

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

PBS, pH 7.2

Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis. Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways. Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production. Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes (By similarity). Mediates the 'Lys-48'-linked deubiquitination of the transcriptional coactivator WWTR1/TAZ leading to its stabilization and inhibition of osteoclastogenesis (By similarity). Deubiquitinates and stabilizes epidermal growth factor receptor EGFR to prevent its degradation and to activate its downstream mediators (By similarity). Modulates oxidative activity in skeletal muscle by regulating key mitochondrial oxidative proteins (By similarity). Enhances the activity of hypoxia-inducible factor 1-alpha/HIF1A by abrogateing its VHL E3 ligase-mediated ubiquitination and consequently inhibiting its degradation.

Recombinant protein corresponding to Human UCHL1

小鼠(Mouse)

人(Human)

Human UCHL1

WB: HEK293, A549 and SK-N-SH whole cell lysates Flow Cytometry: SH-SY5Y cells IF/ICC: HeLa cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

AB02/2F6

Whole IgG