Caspase 6 Mouse mAb

抗体

半胱天冬蛋白酶-6 | 半胱氨酸-天冬氨酸蛋白酶6 | 半胱天冬蛋白酶-6抗体 | CASP6 抗体 | Caspase-6 小鼠单克隆抗体 | 半胱天冬蛋白酶-3小鼠单克隆抗体

Apoptotic protease Mch-2 antibody | Apoptotic protease MCH2 antibody | CASP-6 antibody | CASP6 antibody | CASP6_HUMAN antibody | Caspase 6 antibody | Caspase 6 apoptosis related cysteine protease antibody | Caspase 6 | Caspase-6 antibody | Caspase-6 subun

Ab183843-10μl

10μl

无载体

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

PBS, pH 7.2

Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity; Acts as a non-canonical executioner caspase during apoptosis: localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation; Lamin-A/LMNA cleavage is required for chromatin condensation and nuclear disassembly during apoptotic execution; Acts as a regulator of liver damage by promoting hepatocyte apoptosis: in absence of phosphorylation by AMP-activated protein kinase (AMPK), catalyzes cleavage of BID, leading to cytochrome c release, thereby participating in nonalcoholic steatohepatitis; Cleaves PARK7/DJ-1 in cells undergoing apoptosis; Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP; Cleaves phospholipid scramblase proteins XKR4 and XKR9; In addition to apoptosis, involved in different forms of programmed cell death; Plays an essential role in defense against viruses by acting as a central mediator of the ZBP1-mediated pyroptosis, apoptosis, and necroptosis (PANoptosis), independently of its cysteine protease activity; PANoptosis is a unique inflammatory programmed cell death, which provides a molecular scaffold that allows the interactions and activation of machinery required for inflammasome/pyroptosis, apoptosis and necroptosis; Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death; Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis; Regulates B-cell programs both during early development and after antigen stimulation; Proteolytically cleaves the N protein of coronaviruses such as MERS-CoV and SARS-CoV; The cleavage of MERS-CoV N-protein leads to two fragments and modulates coronavirus replication by regulating IFN signaling. The two fragments produced by the cleavage interact with IRF3 inhibiting its nuclear translocation after activation and reduce the expression of IFNB and IFN-stimulated genes; The same mechanism seems to be used by other coronaviruses such as SARS-CoV and SARS-CoV-2 to enhance their replication.

Recombinant full-length protein corresponding to Human Caspase 6

小鼠(Mouse)

人(Human)

Human Caspase 6

Flow Cytometry: Jurkat cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

AB02/1H7

Whole IgG