Cyclophilin A Mouse mAb

抗体

肽基脯氨酰异构酶 A | 亲环素 A | 环孢素A | 环孢菌素结合蛋白 | 肽基脯氨酰异构酶 A小鼠单克隆抗体 | 亲环素 A小鼠单克隆抗体 | 环孢素A小鼠单克隆抗体 | Cyclophilin A/PPIA抗体

Cyclophilin A antibody | Cyclophilin antibody | CyclophilinA antibody | Cyclosporin A binding protein antibody | Cyclosporin A-binding protein antibody | CYPA antibody | CYPH antibody | Epididymis secretory sperm binding protein Li 69p antibody | HEL S 69

Ab183902-10μl

10μl

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

PBS, pH 7.2

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation; Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans. Inhibits replication of influenza A virus (IAV). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.

Recombinant protein corresponding to Human Cyclophilin A

小鼠(Mouse)

人(Human), 大鼠(Rat), 小鼠(Mouse) | 人(Human),大鼠(Rat),小鼠(Mouse)

Human Cyclophilin A

WB: HeLa, K562, HepG2, A549, Jurkat, A431and NIH/3T3 whole cell lysates; Mouse brain and Rat brain tissue Flow Cytometry: HeLa cells

150.0 KDa

Unconjugated

Mouse IgG1

单克隆抗体

kappa

Protein A purified

EF01/4D12

Whole IgG

Chlorocebus aethiops,Macaca mulatta,Pan paniscus,Pan troglodytes,Piliocolobus tephrosceles,Pongo pygmaeus,Pygathrix nigripes,Rhinopithecus roxellana,Symphalangus syndactylus