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Product details

名称

CD31 Rat mAb (PE-Cy7)

分子类型

抗体

别名

血小板内皮细胞粘附分子1(PECAM1)抗体 | CD31抗体

英文别名

货号

Ab190235-10μg

包装规格

10μg

级别

已验证

浓度

0.5 mg/mL

储存温度

2-8°C储存,避光,禁止冷冻

运输条件

冰袋运输

稳定性与储存

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

储存缓冲液

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

防腐剂

0.05% Proclin300

生化机理

Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).

免疫原

C3H/HeJ mouse hematopoietic progenitor cell line 3

宿主种属

大鼠(Rat)

种属反应性

小鼠(Mouse)

特异性

CD31

阳性对照

Flow Cytometry: C57BL/6 mouse splenocytes

偶联

PE-Cy7

亚型

Rat IgG2a

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein G purified

克隆号

390

Excitation(nm)

Blue Laser(488nm), Green Laser(532nm), Yellow-Green Laser(561nm)

Emission(nm)

774nm

Ex/Em(nm)

Ex:565nm;Em:774nm

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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