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Product details
名称
Moxetumomab (anti-CD22)
分子类型
抗体
别名
莫塞妥莫单抗 | 莫妥莫单抗(抗 CD22)
英文别名
B cell receptor CD22 precursor antibody | B lymphocyte cell adhesion molecule antibody | B-cell receptor CD22 antibody | B-lymphocyte cell adhesion molecule antibody | BL CAM antibody | BL-CAM antibody | BLCAM antibody | CD 22 antibody | CD22 antibody | C
货号
Ab191901-100μg
包装规格
100μg
级别
无动物源
浓度
≥95%(SDS-PAGE&SEC-HPLC)
储存温度
-80℃储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
生化机理
介导 B 细胞与 B 细胞之间的相互作用。可能参与 B 细胞在淋巴组织中的定位。结合硅烷基化糖蛋白;其中之一是 CD45。优先与α-2,6-连接的硅酸结合。与同一细胞表面的硅酸顺式相互作用可掩盖硅酸识别位点。免疫反应中配体诱导的酪氨酸磷酸化似乎参与了 B 细胞抗原受体信号传导的调节。通过与 Src 家族酪氨酸激酶的相互作用发挥正向调节作用,也可能通过其 SH2 结构域招募胞质磷酸酶,通过信号分子的去磷酸化阻断信号转导,从而发挥抑制受体的作用。 翻译后:Tyr-762、Tyr-807 和 Tyr-822 的磷酸化分别参与与 SYK、GRB2 和 SYK 的结合。Tyr-842 的磷酸化参与与 SYK、PLCG2 和 PIK3R1/PIK3R2 的结合。被 LYN 在酪氨酸残基上磷酸化。
宿主种属
人(Human)
种属反应性
人(Human), 食蟹猴(Cynomolgus monkey) | 人(Human),食蟹猴(Cynomolgus monkey)
特异性
CD22
CAS编号和信息
1622075-65-3
SDS-PAGE
146.14 kDa
偶联
Unconjugated
亚型
Human IgG1
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
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「No related articles yet」
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Research chemical ≥95%; HPLC

Research chemical ≥95%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%; HPLC.

item number:Ab191901-100μg
Product model:100μg
level: ≥95%; HPLC
Lead Time:30days
sold 733 Items
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Specifications:

100μg

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