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Product details
名称
Coprelotamab (anti-ERBB2)
分子类型
抗体
别名
库洛妥单抗 | ERBB2抗体 | ERBB2单克隆抗体 | CD340药靶抗体 | CD340单克隆抗体 | CD340抗体 | ERBB2药靶抗体
英文别名
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody | C erb B2/neu protein antibody | CD340 antibody | CD340 antigen antibody | Cerb B2/neu protein antibody | GB-221 | v-erb-b2 erythroblastic leuk
货号
Ab191934-100μg
包装规格
100μg
级别
无动物源
浓度
≥95%(SDS-PAGE&SEC-HPLC)
储存温度
-80℃储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
生化机理
蛋白酪氨酸激酶,是多种细胞表面受体复合物的一部分,但显然需要一个核心受体才能与配体结合。它是神经胶质蛋白-受体复合物的重要组成部分,但神经胶质蛋白并不单独与它相互作用。GP30 是该受体的潜在配体。调节外周微管(MT)的生长和稳定。ERBB2 激活后,MEMO1-RHOA-DIAPH1 信号通路引起细胞膜上 GSK3B 的磷酸化,从而抑制 GSK3B。这就阻止了 APC 和 CLASP2 的磷酸化,使其与细胞膜结合。反过来,与细胞膜结合的 APC 可使 MACF1 定位到细胞膜上,而 MACF1 是微管捕获和稳定所必需的。 在细胞核中参与转录调控。与 PTGS2/COX-2 启动子中的 5'-TCAAATTC-3' 序列结合并激活其转录。参与 CDKN1A 的转录激活;该功能涉及 STAT3 和 SRC。参与 RNA Pol I 转录 rRNA 基因,促进蛋白质合成和细胞生长。
宿主种属
人(Human)
种属反应性
人(Human), 食蟹猴(Cynomolgus monkey) | 人(Human),食蟹猴(Cynomolgus monkey)
特异性
ERBB2
CAS编号和信息
2348469-84-9
SDS-PAGE
145 kDa
偶联
Unconjugated
亚型
Human IgG1
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
「No related articles yet」
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Research chemical ≥95%; HPLC

Research chemical ≥95%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%; HPLC.

item number:Ab191934-100μg
Product model:100μg
level: ≥95%; HPLC
Lead Time:30days
sold 752 Items
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Specifications:

100μg

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