GBR 900 (anti-TrkA)

抗体

TrkA抗体 | TrkA单克隆抗体 | TrkA药靶抗体 | NTRK1抗体 | NTRK1单克隆抗体 | NTRK1药靶抗体

gp140trk antibody | High affinity nerve growth factor receptor antibody | High affinity nerve growth factor receptor precursor antibody | MTC antibody | Neurotrophic tyrosine kinase receptor type 1 antibody | NTRK1 antibody | NTRK1_HUMAN antibody | Oncoge

Ab209831-100μg

100μg

无动物源

≥95%(SDS-PAGE&SEC-HPLC)

-80℃储存,避免反复冻融

超低温冰袋运输

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0

No

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

人(Human)

人(Human), 小鼠(Mouse) | 人(Human),小鼠(Mouse)

NTRK1

150 kDa

Unconjugated

Human IgG1

重组抗体

kappa

Protein A purified

Whole IgG