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名称
INSERM patent anti-DC-SIGN (anti-DC-SIGN)
分子类型
抗体
别名
DC-SIGN抗体 | DC-SIGN单克隆抗体 | DC-SIGN药靶抗体 | CD209药靶抗体 | CD209单克隆抗体 | CD209抗体
英文别名
C type lectin domain family 4 member L antibody | C-type lectin domain family 4 member L antibody | CD 209 antibody | CD209 antibody | CD209 antigen antibody | CD209 antigen-like protein A antibody | CD209 molecule antibody | CD209_HUMAN antibody | Cd209a
货号
Ab209899-100μg
包装规格
100μg
级别
无动物源
浓度
≥95%(SDS-PAGE&SEC-HPLC)
储存温度
-80℃储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
生化机理
表达于未成熟树突状细胞(DC)表面的病原体识别受体,参与初级免疫反应的启动。它被认为介导病原体的内吞,病原体随后在溶酶体内降解。受体返回细胞膜表面,病原体衍生的抗原通过 MHC II 类蛋白呈现给静息的 T 细胞,启动适应性免疫反应。Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2,登革热病毒 gE、Leishmania pifanoi LPG、幽门螺杆菌 LPS 中的 Lewis-x 抗原、肺炎克雷伯菌 LPS 中的甘露糖、结核分枝杆菌 ManLAM 中的二甘露糖和三甘露糖以及曼氏血吸虫 SEA 中的 Lewis-x 抗原。在直流细胞上,它是 ICAM2 和 ICAM3 的高亲和力受体,能与甘露糖样碳水化合物结合。它可能是一种 DC 滚动受体,通过与内皮 ICAM2 结合,介导 DC 原体从血液向组织的跨内皮迁移。在 DC 与 T 细胞之间形成的免疫突触中,似乎通过与 T 细胞上的 ICAM3 结合来调节 DC 诱导的 T 细胞增殖。
宿主种属
人(Human)
种属反应性
人(Human)
特异性
CD209
SDS-PAGE
150 kDa
偶联
Unconjugated
亚型
Human IgG1
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
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Research chemical ≥95%; HPLC

Research chemical ≥95%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%; HPLC.

item number:Ab209899-100μg
Product model:100μg
level: ≥95%; HPLC
Lead Time:30days
sold 269 Items
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Specifications:

100μg

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