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Product details
名称
Jr-141 (anti-TfR)
分子类型
抗体
英文别名
CD 71 antibody | CD71 antibody | CD71 antigen antibody | IMD46 antibody | OTTHUMP00000208523 antibody | OTTHUMP00000208524 antibody | OTTHUMP00000208525 antibody | p90 antibody | sTfR antibody | T9 antibody | TFR 1 antibody | TfR antibody | TfR1 antibody
货号
Ab209906-100μg
包装规格
100μg
级别
无动物源
浓度
≥95%(SDS-PAGE&SEC-HPLC)
储存温度
-80℃储存,避免反复冻融
运输条件
超低温冰袋运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
防腐剂
No
生化机理
细胞通过受体介导的内吞作用将配体占用的转铁蛋白受体吸收到特化的内体中。内体酸化导致铁释放。然后,转铁蛋白-受体复合物被回收到细胞表面,pH 值恢复中性,转铁蛋白与其受体的亲和力随之丧失。转铁蛋白受体是红细胞和神经系统发育所必需的(相似)。第二个配体--遗传性血色素沉着病蛋白 HFE 与转铁蛋白竞争一个重叠的 C 端结合位点。通过铁吸收积极调节 T 细胞和 B 细胞的增殖(PubMed:26642240)。(微生物感染)充当新世界网状病毒的受体:Guanarito、Junin 和 Machupo 病毒的受体。 翻译后:N- 和 O-糖基化、磷酸化和棕榈酰化。血清形式只有糖基化。在 Arg-100 上进行蛋白水解,产生可溶性血清形式(sTfR)。Cys-62 和 Cys-67 上都有棕榈酰化。Cys-62 似乎是棕榈酰化的主要部位。
宿主种属
人(Human)
种属反应性
人(Human), 小鼠(Mouse), 恒河猴(Rhesus monkey), 食蟹猴(Cynomolgus monkey) | 人(Human),小鼠(Mouse),恒河猴(Rhesus monkey),食蟹猴(Cynomolgus monkey)
特异性
TFRC
CAS编号和信息
2140211-48-7
SDS-PAGE
146.02 kDa
偶联
Unconjugated
亚型
Human IgG1
克隆类型
重组抗体
轻链亚型
kappa
纯化方法
Protein A purified
Format
Whole IgG
Safety
「No Dangerous Attributes」
Related
「No upstream and downstream information yet」
Technical Documents
「No technical documents」
Articles
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Research chemical ≥95%; HPLC

Research chemical ≥95%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥95%; HPLC.

item number:Ab209906-100μg
Product model:100μg
level: ≥95%; HPLC
Lead Time:30days
sold 794 Items
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100μg

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