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Product details

名称

c-Kit/CD117 Rat mAb (AF647)

分子类型

抗体

别名

干细胞因子受体(SCFR)抗体 | c-Kit/CD117抗体

英文别名

W | Bs | Fdc | Ssm | SCO1 | SCO5 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog antibody | AF647 anti-mouse CD117 (c-kit) Antibody | CD117 (c-Kit) Monoclonal Antibody (ACK2), AF647 | AF647 Anti-Mouse CD117/c-Kit (ACK2) | v kit Hardy Zucke

货号

Ab209966-10μg

包装规格

10μg

级别

已验证

浓度

0.5 mg/mL

储存温度

2-8°C储存,避光,禁止冷冻

运输条件

冰袋运输

稳定性与储存

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

储存缓冲液

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

防腐剂

0.05% Proclin300

生化机理

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

免疫原

IL-3-dependent mast cells

宿主种属

大鼠(Rat)

种属反应性

小鼠(Mouse)

特异性

c-Kit/CD117

阳性对照

Flow: BALB/C mouse bone marrow cells

偶联

AF647

亚型

Rat IgG2b

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein G purified

克隆号

ACK2

Excitation(nm)

Red Laser(633nm)

Emission(nm)

668nm

Ex/Em(nm)

Ex:650nm;Em:668nm

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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