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Product details

名称

Transferrin Receptor/CD71 Mouse mAb (APC)

分子类型

抗体

别名

转铁蛋白受体(TFR)抗体 | Transferrin Receptor/CD71抗体

英文别名

TFR | TRFR | IMD46 | CD71 antigen | CD71 | CD71TRFR | p90 | T9 | TfR (Transferrin R) | TfR (TransferrinR) | TFR1 | TFRC | TR | transferrin receptor (p90, CD71) | transferrin receptor protein 1 | CD 71 antibody | CD71 antibody | CD71 antigen antibody | IMD

货号

Ab210010-25T

包装规格

25T

级别

已验证

浓度

5 μL/test

储存温度

2-8°C储存,避光,禁止冷冻

运输条件

冰袋运输

稳定性与储存

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

储存缓冲液

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

防腐剂

0.05% Proclin300

生化机理

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

免疫原

Human acute lymphoblastic leukemia cells

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

Transferrin Receptor/CD71

阳性对照

Flow: Jurkat

偶联

APC

亚型

Mouse IgG1

克隆类型

单克隆抗体

纯化方法

Protein G purified

克隆号

OKT-9

Excitation(nm)

Red Laser(633nm)

Emission(nm)

660nm

Ex/Em(nm)

Ex:650nm;Em:660nm

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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