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Product details

名称

ACER2 Antibody

分子类型

抗体

别名

ACER2抗体 | ACER2多克隆抗体

英文别名

货号

Ab213089-10μl

包装规格

10μl

级别

无载体

浓度

1.0 mg/mL

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

储存缓冲液

0.42% Potassium phosphate, 0.87% Sodium chloride, 30% Glycerol, 0.01% Sodium azide, pH 7.3

防腐剂

0.01% Sodium azide

生化机理

Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876).

免疫原

A synthetic peptide derived from human ACER2

宿主种属

兔(Rabbit)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse), 猴(Monkey) | 人(Human),大鼠(Rat),小鼠(Mouse),猴(Monkey)

特异性

ACER2

阳性对照

WB: Mouse testis, Rat kidney, HeLa, Hep G2, MCF7 and A549 lysates.

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rabbit IgG

克隆类型

多克隆抗体

纯化方法

Immunogen affinity purified

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

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Research chemical 10μl; 1. 0 mg

Name: Research chemical 10μl; 1. 0 mg
Brand: 阿拉丁
SKU: Ab213089-10μl

Research chemical 10μl; 1. 0 mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10μl; 1. 0 mg.

item number：Ab213089-10μl

Product model：10μl

level： 10μl; 1. 0 mg

Lead Time：30days

sold 176 Items

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Specifications：

10μl

Qty

Research chemical 10μl; 1. 0 mg

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