Recombinant CD3 Antibody (AF647)

抗体

CD3单克隆抗体 | Anti-CD3抗体 | CD3抗体 | CD3单抗

CD_antigen: CD3e | CD3 antigen, delta subunit | CD3 | CD3d antigen | CD3d antigen, delta polypeptide (TiT3 complex) | CD3d molecule, delta (CD3-TCR complex) | CD3-DELTA | CD3e antigen | CD3e antigen, epsilon polypeptide (TiT3 complex) | CD3e molecule, eps

Ab213111-10μg

10μg

已验证

0.5 mg/mL

2-8°C储存,避光,禁止冷冻

冰袋运输

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

0.05% Proclin300

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G (PubMed:25920998).

γδTCR-positive T-T hybridoma D1

大鼠(Rat)

小鼠(Mouse)

CD3

Flow Cytometry: C57BL/6 mouse splenocytes

AF647

Rat IgG2b

重组抗体

kappa

Protein G purified

P49A24

Red Laser(633nm)

668nm

Ex:650nm;Em:668nm

Whole IgG