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Product details

名称

Recombinant c-Kit Antibody (PE)

分子类型

抗体

别名

英文别名

货号

Ab213867-10μg

包装规格

10μg

级别

已验证

浓度

0.5 mg/mL

储存温度

2-8°C储存,避光,禁止冷冻

运输条件

冰袋运输

稳定性与储存

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

储存缓冲液

Liquid in PBS pH 7.4, containing 1% BSA and 0.05% Proclin300.

防腐剂

0.05% Proclin300

生化机理

Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

免疫原

Mouse bone marrow mast cells

宿主种属

大鼠(Rat)

种属反应性

小鼠(Mouse)

特异性

Mouse c-Kit

阳性对照

Flow Cytometry: Mouse bone marrow cells

偶联

亚型

Rat IgG2b

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

P80D41

Excitation(nm)

Blue Laser(488nm), Green Laser(532nm), Yellow-Green Laser(561nm)

Emission(nm)

575nm

Ex/Em(nm)

Ex:565nm;Em:575nm

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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