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Product details

名称

CD31 Mouse mAb

分子类型

抗体

别名

英文别名

货号

Ab216302-10μl

包装规格

10μl

级别

无载体

浓度

≥95%(SDS-PAGE)

储存温度

-20°C储存

运输条件

超低温冰袋运输

稳定性与储存

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

储存缓冲液

PBS, pH 7.2

生化机理

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis (By similarity).

免疫原

Recombinant protein corresponding to Human CD31

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

Human CD31

阳性对照

WB: HUVEC, THP-1 and Jurkat whole cell lysates

SDS-PAGE

150.0 KDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

单克隆抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

AB03/5B2

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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