PIVKA II Mouse mAb

抗体

异常凝血酶原抗体 | 异常凝血酶原单克隆抗体 | 异常凝血酶原包被抗体 | PIVKA II抗体 | PIVKA II单克隆抗体 | PIVKA II包被抗体

PIVKA-II antibody | Anti-PIVKA-II | PIVKA II antibody | Anti-PIVKA II

Liquid

Ab216779-10μg

10μg

≥90%(SDS-PAGE)

2-8°C储存

冰袋运输

长期储存2-8℃（24个月）；收货后建议分装。

20mM PBS, 0.05% ProClin 300, pH 7.2-7.4

0.05% ProClin 300

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Recombinant protein.

小鼠(Mouse)

人(Human)

PIVKA II

150 kDa

Unconjugated

Mouse IgG1

单克隆抗体

kappa

Antigen affinity chromatography

9A6

[Ab216778] PIVKA II Mouse mAb as Capture antibody in CLIA, ELISA

Whole IgG