Recombinant CD3 Antibody

抗体

白细胞分化抗原3 | 分化簇3 | T3复合物 | T 细胞受体复合物的 CD3 epsilon 亚基 | CD3e | CD3 ε 抗体 | Anti-CD3e抗体 | 小鼠抗人CD3 epsilon抗体

Ab219596-10μg

10μg

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C long time. Upon delivery aliquot. Avoid freeze / thaw cycle.

PBS, pH 8.0

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx.

Human infant thymocytes and peripheral blood lymphocytes from a Sézary Syndrome donor

小鼠(Mouse)

人(Human)

Human CD3ε

Flow Cytometry: Human peripheral blood lymphocytes

150 kDa

Unconjugated

Mouse IgG1

重组抗体

kappa

Protein A purified

P93B35