Recombinant HLA-DR Antibody

抗体

抗人类白细胞抗原-DR | HLA-DR抗体 | Anti-HLA-DR抗体 | 小鼠抗人HLA_DR抗体

FLJ51114 | histocompatibility antigen HLA-DR alpha | HLA class II histocompatibility antigen, DR alpha chain | HLADR | HLA-DR | HLA-DRA | HLA-DRA1 | major histocompatibility complex, class II, DR alpha | MHC cell surface glycoprotein | MHC class II antige

Ab219607-10μg

10μg

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

PBS, pH 6.0

An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules.

Human lymphoblastoid B-cell line RPMI 8866

小鼠(Mouse)

人(Human)

Human HLA-DR

Flow Cytometry: Human peripheral blood lymphocytes; Raji cells

150 kDa

Unconjugated

Mouse IgG2a

重组抗体

kappa

Protein A purified

P22B24

Whole IgG