Recombinant IL3RA/CD123 Antibody

抗体

白介素3受体α链 | 白细胞介素3受体亚单位α | CD123抗体 | IL-3RA抗体

CD123 antigen | CD123 | hIL3Ra | hIL-3Ra | IL-3 R alpha | IL-3 receptor subunit alpha | IL3R alpha | IL-3R alpha | IL-3R subunit alpha | IL3R | IL3RA | IL-3Ra | IL-3R-alpha | IL3RAY | IL3RX | IL3RY | interleukin 3 receptor, alpha (low affinity) | interleu

Ab219621-10μg

10μg

无动物源

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

PBS, pH 8.0

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). Post-translational modification Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway.

Human IL-3Rα transfected COS cells.

小鼠(Mouse)

人(Human)

Human Interleukin-3 receptor subunit alpha

Flow Cytometry: Human peripheral blood lymphocytes

150 kDa

Unconjugated

Mouse IgG1

重组抗体

kappa

Protein A purified

P45B45

Whole IgG