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名称

Recombinant CD3 Antibody

分子类型

抗体

别名

英文别名

货号

Ab220319-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

储存缓冲液

PBS, pH 7.4

生化机理

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Also participates in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. In addition to its role as a TCR coreceptor, it serves as a receptor for ITPRIPL1. Ligand recognition inhibits T-cell activation by promoting interaction with NCK1, which prevents CD3E-ZAP70 interaction and blocks the ERK-NFkB signaling cascade and calcium influx. Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.

免疫原

Recombinant Human CD3 Proteins

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

Human CD3

阳性对照

Flow Cytometry: Human peripheral blood lymphocytes.

SDS-PAGE

150.0 KDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

重组抗体

轻链亚型

lambda

纯化方法

Protein A purified

克隆号

P13A31

Format

Whole IgG

预测反应种属

Gorilla gorilla gorilla

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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