HLA-DR Mouse mAb

抗体

人类白细胞抗原DRA | 人类白细胞抗原DRA抗体 | 人类白细胞抗原DRA小鼠单克隆抗体 | 小鼠抗人人类白细胞抗原DRA抗体 | HLA-DRA抗体 | HLA-DRA1抗体.

DASS-397D15.1 antibody | DR alpha chain antibody | DR alpha chain precursor antibody | DRA_HUMAN antibody | DRB1 antibody | DRB4 antibody | FLJ51114 antibody | Histocompatibility antigen HLA DR alpha antibody | Histocompatibility antigen HLA-DR alpha anti

Ab220467-10μl

10μl

无载体

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融。

PBS, pH 7.2

An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells. Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes. In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins. Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance. The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides. The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules. Ubiquitinated by MARCHF1 or MARCHF8 at Lys-244 leading to down-regulation of MHCII. When associated with ubiquitination of the beta chain at 'Lys-254', the down-regulation of MHCII may be highly effective.

Recombinant protein corresponding to Human HLA-DRA

小鼠(Mouse)

人(Human)

Human HLA-DRA

WB: Raji and Ramos whole cell lysates IF/ICC: Raji cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

H05/10C6

Whole IgG

Gorilla gorilla,Pan paniscus