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Product details

名称

Recombinant CD5 Antibody

分子类型

抗体

别名

分化簇5 | 淋巴细胞表面抗原5 | CD5单克隆抗体 | CD5抗体

英文别名

货号

Ab222902-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

Store at 2-8℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

储存缓冲液

PBS, pH 7.4

生化机理

Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation (By similarity). Modulates B-cell biology through ERK1/2 activation in a Ca2+-dependent pathway via the non-selective Ca2+ channel TRPC1, leading to IL-10 production (By similarity).

免疫原

Mouse Thymus / Spleen

宿主种属

大鼠(Rat)

种属反应性

小鼠(Mouse)

特异性

Mouse CD5

阳性对照

Flow Cytometry: C57BL/6 mouse splenocytes

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Rat IgG2a

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

P27B11

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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