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Product details

名称

Recombinant CD27 Antibody

分子类型

抗体

别名

肿瘤坏死因子受体超家族成员7 | CD27抗体 | CD27/TNFRSF7单克隆抗体

英文别名

货号

Ab222917-10μg

包装规格

10μg

级别

无动物源

浓度

≥95%(SDS-PAGE)

储存温度

-20°C储存,避免反复冻融

运输条件

超低温冰袋运输

稳定性与储存

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

储存缓冲液

PBS, pH 8.0

生化机理

Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity).

免疫原

Human Thymocytes

宿主种属

小鼠(Mouse)

种属反应性

人(Human)

特异性

Human CD27

阳性对照

Flow Cytometry: Human peripheral blood lymphocytes

SDS-PAGE

150 kDa

偶联

Unconjugated

亚型

Mouse IgG1

克隆类型

重组抗体

轻链亚型

kappa

纯化方法

Protein A purified

克隆号

P08D01

Format

Whole IgG

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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Consultation

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