NQO1 Mouse mAb

抗体

NAD (P)H：醌氧化还原酶1 | NQO1抗体 | 小鼠抗人NQO1抗体 | NQO1小鼠单克隆抗体

Azoreductase antibody | Cytochrome b 5 reductase antibody | DHQU antibody | DIA 4 antibody | DIA4 antibody | Diaphorase (NADH/NADPH) (cytochrome b 5 reductase) antibody | Diaphorase (NADH/NADPH) antibody | Diaphorase 4 antibody | Dioxin inducible 1 antibo

Ab224769-10μl

10μl

无载体

≥95%(SDS-PAGE)

-20°C储存,避免反复冻融

超低温冰袋运输

短期储存2-8℃（1-2周）；长期储存-20℃（24个月）；收货后建议分装，避免反复冻融.

PBS, pH 7.4

Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome.

Recombinant full length protein corresponding human NQO1

小鼠(Mouse)

人(Human)

Human NQO1

WB: HepG2, HeLa, MCF-7 and A549 whole cell lysates Flow Cytometry: MCF-7 cells

150.0 KDa

Unconjugated

Mouse IgG2b

单克隆抗体

kappa

Protein A purified

AB03/1H11

Whole IgG