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Product introduction
藜芦胺是一种哌啶生物碱,是由藜芦烷的14,15,16,17-四脱氢衍生物,在3-和23-位有两个羟基。它来源于藜芦烷的氢化物。
Chinese name
黎芦碱
English name
(2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol
Chinese alias
-
English alias
veratramine; Vreaframine; (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol; NSC 17821; NSC 2388; AIDS011940; (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol; NSC 23880
CAS number
60-70-8
molecular formula
C27H39NO2
molecular weight
409.6
Exact mass
-
PSA
52.5
Logp
4.3
Safety
  • Hazard summary: 紧急处理:植物-藜芦生物碱;过量可因中枢性呼吸抑制导致死亡;藜芦生物碱(如黑根、假升麻和臭菘)可引起胃肠炎、心动过缓、感觉异常、房室传导阻滞和晕厥;[Olson, p. 376-92]
  • Harmful effect: 神经毒素 - 其他中枢神经系统神经毒素
  • Toxicity summary: 藜芦胺对中枢神经系统产生特征性兴奋作用,引起震颤和特征性"挣扎"行为。这种行为性兴奋伴有下丘脑血清素含量的变化。中枢血清素激动剂甲麦角新碱在5-15 mg/kg的剂量下对藜芦胺的作用产生剂量依赖性抑制,而对氯苯丙氨酸没有影响。(A15440)
  • Special Reports: 一篇关于藜芦胺及其选择性拮抗拟交感胺和其他物质正性变时作用的综述,附有许多参考文献。[KRAYER O; 关于藜芦胺的抗加速活性及其发现的一些回忆;DOSTIZH SOVREM FARMAKOL 59-70 (1976)]
  • Hazard categories and classifications: 急性毒性 4 (90.5%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Natural Pollution Sources: 来自藜芦(Veratrum grandiflorum (Maxim) Loes)和绿藜芦(V. viride Ait)的二级碱,百合科。分离与结构:Saito, Bull Chem Soc Japan 15, 22 (1940); Jacobs, Craig, J Biol Chem 160, 555 (1945)...全合成:Masamune et al, J Am Chem Soc 89, 4521 (1967)...
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Research chemical CAS 60-70-8 HPLC ≥98% 10mg

Research chemical CAS 60-70-8 HPLC ≥98% 10mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:B20716-10mg
Product model:10mg
level: HPLC ≥98% 10mg
Lead Time:30days
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