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Product introduction
加替沙星是一种单羧酸,是4-氧代-1,4-二氢喹啉-3-甲酸,其氮原子被环丙基取代,6、7、8位分别被氟、3-甲基哌嗪-1-基和甲氧基取代。加替沙星是第四代氟喹诺酮类抗生素,与该家族其他成员一样,抑制细菌II型拓扑异构酶。它具有抗菌剂、抗感染剂和EC 5.99.1.3 [DNA拓扑异构酶(ATP水解)]抑制剂的作用。它是一种喹诺酮、喹啉单羧酸、有机氟化合物、N-芳基哌嗪和喹诺酮类抗生素。
Chinese name
加替沙星, 拓扑异构酶 IV 抑制剂
English name
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Chinese alias
加替沙星
English alias
HMS3259P06 | AM-1155 | Spectrum3_000999 | PD-135432 | CHEBI:5280 | RKL10068 | 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid | AKOS016340697 | AM 1155 | NC00702 | SCHEMBL22591 | Spectrum5_001468 | HMS2093G06 |
CAS number
112811-59-3
molecular formula
C19H22FN3O4
molecular weight
375.4
Exact mass
-
PSA
82.1
Logp
-0.7
Safety
  • Treatment: 发生急性口服过量时,应通过诱导呕吐或洗胃排空胃内容物。应仔细观察患者(包括心电图监测)并进行对症和支持治疗。应保持充分水合。(L1712)
  • exposure pathway: 眼科用药。口服给药后从胃肠道吸收良好,加替沙星的绝对生物利用度为96%
  • Toxicity summary: 加替沙星的杀菌作用源于抑制拓扑异构酶II(DNA旋转酶)和拓扑异构酶IV,这些酶是细菌DNA复制、转录、修复和重组所必需的。
  • Health Effects: 抗生素耐药性
  • Symptoms and Signs: 抗生素最常见的副作用是腹泻、恶心、呕吐。使用抗生素也可能导致口腔、消化道和阴道的真菌感染。
  • Hazard categories and classifications: 急性毒性 4 (97.5%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Effects During Pregnancy and Lactation: ◉ 对哺乳和母乳的影响
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Research chemical CAS 112811-59-3 HPLC ≥99% 100mg

Yuanye Research chemical CAS 112811-59-3 HPLC ≥99% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:B25457-100mg
Product model:100mg
level: HPLC ≥99% 100mg
Lead Time:30days
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