- Harmful effect： 最后，普鲁卡因胺已知可引起某些血液疾病。普鲁卡因胺已知可引起骨髓毒性，导致全血细胞减少或粒细胞缺乏症；这通常是由于超敏反应或不同的免疫机制所致。
- Toxicity summary： 普鲁卡因酰胺过量毒性罕见，因为它通常在监测环境下静脉给药。然而，可能在意外给予毒性剂量或肾功能不全患者接受不准确剂量时发生。普鲁卡因酰胺口服过量情况下，需要咨询医学毒理学家和地区毒物控制中心。治疗理论上应类似于其他1A类抗心律失常药物（包括奎尼丁和丙吡胺）的过量，患者接受高渗碳酸氢钠以阻断钠通道。
- interaction： 研究表明，普鲁卡因酰胺在猫中...可能延长并增强琥珀胆碱引起的神经肌肉阻滞。
- Hepatotoxicity： 可能性评分：C（可能是引起明显肝损伤的罕见原因）。
- Human toxicity extract： ...IV给药... 低血压常见，可导致心血管衰竭、惊厥和冠状动脉供血不足。严重的心律紊乱，如心室停搏或心室颤动... 肌内注射后可能出现低血压，但通常不严重。
- Non-human toxic extract： ...动物快速大剂量静脉注射会引起震颤，死亡可能由呼吸抑制导致。
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical CAS 51-06-9 HPLC ≥98% 1g
Yuanye Research chemical CAS 51-06-9 HPLC ≥98% 1g, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
