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Product introduction

Benzamil (Benzylamiloride)，是 Amiloride 类似物，是一种 Na+/Ca2+ 交换体 (NCX) 抑制剂，(IC50~100 nM)。Benzamil 也是一种非选择性 Deg/epithelial sodium channels (ENaC) 阻滞剂，能增强肌源性血管收缩。Benzamil 抑制 TRPP3 介导的 Ca2+ 激活电流，IC50 为 1.1 μM。 Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.

Specs ⸢ View details ⸥

Chinese name

苯扎咪, ASIC1 通道阻断剂

English name

Benzamil

Chinese alias

English alias

CAS number

2898-76-2

molecular formula

C13H14ClN7O

molecular weight

319.75 g/mol

Exact mass

PSA

145.000 Å²

Logp

1.700

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