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Bcl-2抑制剂包含两种互变异构体的混合物。一种有效的，可渗透细胞的Bcl-2抑制剂与Bak BH3肽竞争体外结合Bcl-2和Bcl-x |的作用（IC | 50 | = 10μM和7μM）。Bcl-2抑制剂还降低了具有高Bcl-2表达（IC | 50 | = 4μM）的HL-60细胞系的细胞活力和生长。在具有高Bcl-2表达的癌细胞中也以剂量依赖的方式诱导凋亡，而对具有低Bcl-2表达的癌细胞几乎没有影响。 Bcl-2 Inhibitor contains a mixture of two tautomers. A potent, cell-permeable, Bcl-2 inhibitor competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-x|in vitro|(IC|50|=10 μM and 7 μM, respectively). Bcl-2 Inhibitor also reduces cell viability and growth in HL-60 cell lines with high Bcl-2 expression (IC|50|= 4 μM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.

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Chinese name

Bcl-2 Inhibitor

English name

Bcl-2 Inhibitor

Chinese alias

Bcl-2 抑制剂

English alias

CAS number

383860-03-5

molecular formula

C16H16N2O4

molecular weight

300.3 g/mol

Exact mass

≥97%

PSA

77.300 Å²

Logp

2.800

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