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产品介绍 Brevilin A (6-O-Angeloylplenolina) 是一种从Centipeda minima分离得到的倍半萜内酯，是 STAT3 的选择性抑制剂，可通过阻断JAKs酪氨酸激酶结构域 JH1 来减弱 JAKs 的活性。Brevilin A 可通过线粒体途径和 PI3K/AKT/mTOR 失活来诱导结肠腺癌细胞CT26的凋亡和自噬。靶点：STAT3； JAK Product description Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Targets：STAT3； JAK

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Chinese name

Brevilin A

English name

Brevilin A

Chinese alias

短叶老鹳草素 A | 布雷维林A

English alias

[(1S,3aR,5R,5aR,8aR,9S,9aR)-1,5,8a-trimethyl-2,8-dioxo-3a,4,5,5a,9,9a-hexahydro-1H-azuleno[6,5-b]furan-9-yl] (Z)-2-methylbut-2-enoate | AC-34175 | EKT624Z4TZ | Ambros-2-en-12-oic acid, 6alpha,8beta-dihydroxy-4-oxo-, 12,8-lactone, 2-methylcrotonate, (Z)- |

CAS number

16503-32-5

molecular formula

C2OH26O5

molecular weight

346.42 g/mol

Exact mass

≥98%

PSA

69.700 Å²

Logp

2.300

Technical Documents

16503-32-5 | Brevilin A.pdf
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