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Product introduction
苄氟噻嗪是一种磺胺,由7-磺酰氨基-3,4-二氢-2H-1,2,4-苯并噻二嗪 1,1-二氧化物组成,其中6位氢被三氟甲基取代,3位氢被苄基取代。它具有利尿剂和降压剂的作用。它是一种磺胺和苯并噻二嗪。
Chinese name
苄氟噻嗪
English name
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Chinese alias
-
English alias
BENDROFLUMETHIAZIDE; BENDROFLUMETHIAZIDE-D5; 3-BENZYL-6-TRIFLUOROMETHYL-7-SULFAMOYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE; 2h-1,2,4-benzothiadiazine-7-sulfonamide,3,4-dihydro-3-(phenylmethyl)-6-(triflu; 2h-1,2,4-benzothiadiazine-7-sulfonamide,
CAS number
73-48-3
molecular formula
C15H14F3N3O4S2
molecular weight
421.4
Exact mass
-
PSA
135
Logp
1.2
Safety
  • Storage conditions: 苄氟噻嗪片应储存在密闭容器中,室温保存,避免过度受热。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Regulatory information: 新西兰EPA化学品清单状态:苄氟噻嗪:没有单独批准,但可在适当的团体标准下使用
  • Primary Hazards: 未分类
  • Human toxicity extract: 可能抑制泌乳,但与母乳喂养兼容/SRP:/。/噻嗪类利尿剂,来自表格/
  • Other safety information: 化学品评估:IMAP评估 - 2H-1,2,4-苯并噻二嗪-7-磺酰胺, 3,4-二氢-3-(苯甲基)-6-(三氟甲基)-, 1,1-二氧化物:人类健康I级评估
  • non-human toxicity value: LD50 小鼠静脉注射 395 mg/kg
  • Hazard categories and classifications: 未分类
  • Antidote and first aid: 噻嗪类利尿剂过量应立即进行胃排空,然后进行支持性对症治疗,并监测血清电解质浓度和肾功能。/噻嗪类利尿剂/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 苯氟噻嗪已被用于抑制泌乳,口服剂量为每天5毫克,每日两次,连续5天,以及早晨10毫克和下午5毫克的剂量。利尿剂对这些有效抑制泌乳措施的附加贡献尚未研究。关于强效利尿剂对已建立的、正在进行的泌乳的影响没有数据。
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Research chemical

Research chemical; supplied for laboratory research, analysis, inspection, and scientific procurement use.

item number:B425733-1ml
Product model:1ml
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