Nigranoic acid is a triterpenoid separated from Schisandra chinensis . Nigranoic acid inhibits HIV-1 reverse transcriptase . Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model In Vivo Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion modelDosage: 1 mg/kg Administration: Intragastric; 6 hours and 2 hours before brain ischemia Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. Form:Solid IC50& Target:HIV-1 reverse transcriptase