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Product introduction

Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.

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Chinese name

双砜-PEG4-琥珀酰亚胺酯

English name

Bis-sulfone-PEG4-NHS Ester

Chinese alias

English alias

CAS number

2055047-19-1

molecular formula

C40H48N2O14S2

molecular weight

845 g/mol

Exact mass

≥93%

PSA

Logp

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