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Product details

名称

BF 227

英文名称

BF 227

货号

B646183-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

BF 227 is a candidate for an amyloid imaging probe for PET, with a K i of 4.3 nM for Aβ1-42 fibrils . In Vitro BF-227 has a high binding affinity for Aβ1-42 fibrils. The K i value for Aβ1-42 fibrils in competitive binding assay using [ 125 I]BF-180 is 4.3±1.3 nM in BF-227 (K d value of [ 125 I]BF-180: 10.8±1.5 nM). [ 11 C]BF-227 is a PET tracer. The AUC for BF-227 (0.994) is much higher than that for FDG (0.839), indicating that BF-227 is more sensitive as well as more specific than FDG in diagnosing AD. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 4.3 nM (Aβ1-42)

生化机理

BF 227 是 PET 淀粉样蛋白成像探针的候选者，对 Aβ1-42 纤维的 K i 为 4.3 nM。

CAS号

845647-80-5

分子式

C16H16FN3O2S

分子量

333.38 g/mol

PubChem编号

10404577

Isomeric SMILES

CN(C)C1=NC=C(S1)/C=C/C2=NC3=C(O2)C=C(C=C3)OCCF

IIUPAC Name

5-[(E)-2-[6-(2-fluoroethoxy)-1,3-benzoxazol-2-yl]ethenyl]-N,N-dimethyl-1,3-thiazol-2-amine

INCHI

1S/C16H16FN3O2S/c1-20(2)16-18-10-12(23-16)4-6-15-19-13-5-3-11(21-8-7-17)9-14(13)22-15/h3-6,9-10H,7-8H2,1-2H3/b6-4+

InChi Key

GSZMUPHKOPBPPS-GQCTYLIASA-N

Smiles

CN(C)C1=NC=C(S1)C=CC2=NC3=C(O2)C=C(C=C3)OCCF

PubChem CID

10404577

溶解性

DMSO : 62.5 mg/mL (187.47 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

333.095 Da

单同位素质量Monoisotopic Mass

333.095 Da

拓扑极表面积Topological Polar Surface Area

79.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

413

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.9

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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