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Product details

名称

BAN ORL 24

英文名称

BAN ORL 24

货号

B646299-50mg

包装规格

50mg

浓度

≥98%

储存温度

避光,-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

BAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with K I value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic In Vitro BAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC 50 values of 50 μM and 0.224 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 miceDosage: 10 mg/kg Administration: 10 mg/kg; i.v. Result: Caused inhibition of BPRIM97-induced antinociception at 90-min postinjection. Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min. Form:Solid IC50& Target:Ki: 0.24 nM (NOP in CHO cell),IC50: 50 μM (NOR),0.224 μM (MOR)

生化机理

BAN ORL 24 是一种痛觉素/孤儿素 FQ（N/OFQ）肽受体（NOP）拮抗剂。BAN ORL 24 对痛觉素（NOP）受体具有拮抗作用，在 CHO 细胞中的 K I 值为 0.24 nM。BAN ORL 24 可用于癌症和镇痛研究。

CAS号

1401463-54-4

分子式

C27H35N3O2.2HCl

分子量

506.51 g/mol

PubChem编号

56840444

Isomeric SMILES

C1C[C@@H](N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl

IIUPAC Name

(2R)-1-benzyl-N-(3-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylpropyl)pyrrolidine-2-carboxamide;dihydrochloride

INCHI

1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27;;/h1-5,8-11,25H,6-7,12-21H2,(H,28,31);2*1H/t25-;;/m1../s1

InChi Key

NEEVITHVDIQNJY-KHZPMNTOSA-N

Smiles

C1CC(N(C1)CC2=CC=CC=C2)C(=O)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl

PubChem CID

56840444

溶解性

DMSO : 200 mg/mL (394.86 mM; Need ultrasonic) H2O : 100 mg/mL (197.43 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

505.226 Da

单同位素质量Monoisotopic Mass

505.226 Da

拓扑极表面积Topological Polar Surface Area

44.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

612.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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