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名称

7-BIA

英文名称

7-BIA

货号

B646782-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC 50 of ~1-3 μM In Vitro 7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC 50 values of ~1–3 μM and 40 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo 7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions) Dosage: 10 mg/kg, 20 mg/kg Administration: Given i.p.; only once Result: Reduced cocaine self-administration in highly experienced WT mice. Form:Solid IC50& Target:IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)

生化机理

7-BIA 是一种受体型蛋白酪氨酸磷酸酶 D (PTPRD) 抑制剂，其 IC 50 约为 1-3 μM。

CAS号

1313403-49-4

分子式

C15H18O6

分子量

294.30 g/mol

PubChem编号

137321149

IIUPAC Name

7-butoxy-3-hydroxy-6-methoxy-1-oxo-3,4-dihydroisochromene-5-carbaldehyde

INCHI

1S/C15H18O6/c1-3-4-5-20-12-6-10-9(7-13(17)21-15(10)18)11(8-16)14(12)19-2/h6,8,13,17H,3-5,7H2,1-2H3

InChi Key

DAVCIYWSVYDJKW-UHFFFAOYSA-N

Smiles

CCCCOC1=C(C(=C2CC(OC(=O)C2=C1)O)C=O)OC

PubChem CID

137321149

溶解性

DMSO : 125 mg/mL (424.74 mM; Need ultrasonic) Ethanol : 50 mg/mL (169.89 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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