BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC 50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity In Vitro BRD-K98645985 (30 µM; 18 hours) treatment shows a 5-fold increase in Bmi1 , 2.6-fold increase in Ring1 , and 3.3-fold decrease in Fgf4. BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:BAF transcriptional repression 2.37 μM (EC 50 ) HIV-1